that definitely can be done. Is your car on standard height or lowered a lot?
I had SSR FM 15x8 -2 on my car with tire size 195/50-15 and the inside fender flange made flat without rubbing. It gave a nice flushed look.
Without any modification to the fender flanges I would choose 15x7.5 +4 all around.
This was my setup (15x8 -2) before I got wide fenders.
